Author:
Ahmad AB Yosef Kinani and Mohammed H. Al‐Bayati
Page: 23-29
Published online: 30 Jul 2025
https://doi.org/10.36478/acejrsb.2025.23.29
This study aimed to improve the stability and solubility of Garcinia indica's bioactive compounds, the HCA part is forming the aqueous extract into a nanosuspension using Poloxamer 407 and Tween 80 (HPH) through high‐pressure homogenization. The optimized nanosuspension formula is estimated by SEM (to study the morphology and size; the spherical nanoparticles should be between 400‐200 nm) and Zeta Potential (‐35 mV to indicate the stability), to demonstrate the aggregation prevention and the effective particle size reduction. HPLC study is confirmed HCA loading of active drug. This study shows promise for enhancing the physicochemical properties of Garcinia indica's bioactive compounds for pharmaceutical applications, and the study can be supported by further investigation in‐vitro and in‐vivo studies.