Author:
Hazim Muttair Hussein, Anwar S. Saihood and Ghada Basil Ali Alomashi
Page: 5-10
Published online: 13 Jun 2025
https://doi.org/10.36478/acerjmb.2025.5.10
Chickenpox is a common childhood disease that usually confers lifelong immunity. Although chickenpox is usually not very serious, it is still a burden on the health care system. Chickenpox is uncommon in adults, and when it occurs, adolescents and adults may experience related‐complications. IL‐10 in infectious diseases interferes with both innate and adaptive protective immunity and contributes to the persistence of bacteria and viruses. Individual variations in IL‐10 levels are thought to result primarily from polymorphisms in the gene encoding IL‐10. Understanding the role of cytokines in many diseases allows, on the one hand, to choose a more specific treatment for each patient and on the other hand, to predict the likelihood of developing a disease or the severity of its course. ELISA was used to detect IgM as well as to measure IL‐10 levels. Tetra‐ARMS‐PCR was used to determine the polymorphism of IL‐10 gene A/G (rs1800896). The mean level of IL‐10 in serum of chickenpox patients was significantly higher compared to subjects in the healthy control group. Serum levels of IL‐10 were also lower in patients with mutant genotype (GG) compared to other genotypes, but the difference was not significant.