TY  - JOUR
T1  - Association Study Between IL‐10 Level and Polymorphism of the Gene Encoding IL‐10 (rs1800896) in the Course of Chickenpox in Wasit Province, Iraq
AU - Saihood, Anwar
        AU - Hussein, Hazim
        AU - Alomashi, Ghada Basil
        
JO  - ACE Research Journal of Microbiology and Biotechnology
VL  - 5
IS  - 1
SP  - 5
EP  - 10
PY  - 2025
DA  - 2001/08/19
SN  - 2520-3975
DO  - 10.36478/acerjmb.2025.5.10
UR  - https://theacepublications.com/article-detail.php?art=262-ACE-RJMB
KW  - chickenpox
KW  - IL‐10
KW  - polymorphism
AB  - Chickenpox is a common childhood disease that usually confers lifelong
immunity. Although chickenpox is usually not very serious, it is still a
burden on the health care system. Chickenpox is uncommon in adults,
and when it occurs, adolescents and adults may experience
related‐complications. IL‐10 in infectious diseases interferes with both
innate and adaptive protective immunity and contributes to the
persistence of bacteria and viruses. Individual variations in IL‐10 levels
are thought to result primarily from polymorphisms in the gene
encoding IL‐10. Understanding the role of cytokines in many diseases
allows, on the one hand, to choose a more specific treatment for each
patient and on the other hand, to predict the likelihood of developing
a disease or the severity of its course. ELISA was used to detect IgM as
well as to measure IL‐10 levels. Tetra‐ARMS‐PCR was used to determine
the polymorphism of IL‐10 gene A/G (rs1800896). The mean level of
IL‐10 in serum of chickenpox patients was significantly higher compared
to subjects in the healthy control group. Serum levels of IL‐10 were also
lower in patients with mutant genotype (GG) compared to other
genotypes, but the difference was not significant.
ER  -