Effects of Letrozole and Metformin Versus Metformin Alone on Ovarian Activities and Gonadotropin‐Releasing Hormone Receptor Antibodies (GnRh) in Iraqi Patients With Polycystic Ovarian Syndrome. (PCOS)

Author: Shatha Salih Mahdi and Sinaa A. Kadhim
Page: 48-52
Published online: 10 Jul 2024

https://doi.org/acejphcm.2024.48.52

Abstract:

In recent times, an increasing emphasis has been placed on a novel category of autoantibodies. This particular group of autoantibodies specifically targets the receptors that are coupled to G protein (GPCRs), primarily focusing on the 2nd extracellular loop (ECL2). These autoantibodies have the ability to either trigger or block particular GPCR signaling pathways, thus playing a crucial role in the pathogenesis of numerous ailments such as PCOS. The goal of the research is exploring the effects of Letrozole and metformin versus the sole use of metformin on ovary activities and GnRh antibodies in Iraqi subjects complaining of PCOS. The current investigation enrolled seventy five women with an age range of 20‐

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