Author:
Mohammed Faris Jabaz
Page: 37-41
Published online: 08 Jul 2024
https://doi.org/acejphcm.2024.37.41
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by oral ulcer (Ou) as one of the SLE manifestations, some factors are contributed in SLE etiology, Reactive oxygen species (ROS) are one of these factors. A cross sectional study aim to evaluate the ROS role in oral ulcer occurrence, number and types in SLE patients. The results demonstrate significant changes in age, non‐sig in BMI and patients duration average was 6.87 years. The ROS level showed significant‐elevation in SLE group (p = 0.000). Patients classified according to oral ulcer occurrence results found high percentage of patients have Ou (72.60)% with non‐sig changes in age, BMI, duration and ROS level. finding also showed (48.4%) of patients have single Ou, low percentage (24.3%) have multiple Ou and (27.4%) without Ou with non‐sig changes in all study variation and slightly elevation of ROS in a single ulcer, five types of oral ulcer including mouth, lips, tongue, pharynx and gum, high percent of patients have mouth ulcer (33.9%), then tongue (14.5%) and low percent was observed in lips (3.9%) and variables have non‐sig changed, ROS was elevated in mouth Ou and decreased in lips oral Ou, other types have slightly changes in compare with patients without Ou, The ROS levels in each oral ulcer types in compare with patient without this types didn’t significant associated with ROS levels (p = 0.143, 0.366, 0.394, 0.471, 0.729) for mouth, lips, tongue, pharynx and gum respectively. the current finding proved robust association of SLE with ROS level but non‐significant relation with oral ulcer incidence, type and number in SLE patients.