Author:
Ahmed Jabbar Abbas Alsaidi, Maha Fadhil Smaism and Ali Mohammed Hussain Alkazzaz
Page: 1-6
Published online: 30 Dec 2023
https://doi.org/acejrsb.2023.1.6
Autoimmune, systemic, chronic and inflammatory rheumatoid arthritis is characterized by symmetric, polyarticular pain and tumefaction, morning stiffness and lethargy. The aim of this study is to evaluate of galectin‐3 and galectin‐3 binding protein and their role in rheumatoid arthritis pathogenesis. Also evaluation of gene level of galectin‐3 gene polymorphism in rheumatic patients to predict its relationship with rheumatoid arthritis in future. The case control group was made up of 45 additional, presumably healthy persons, whereas the ill group was made up of 45 rheumatic patients. A study was carried out in the Merjan teaching hospital in Hilla city and private clinics between February 2022 to January 2023. An ELISA was used to calculate the serum concentrations of galectin‐3, galectin‐3 binding protein (enzymelinked immunosorbent assay), galectin‐3 genotyping is measured by tetra ARMS ‐PCR. SPSS software 26 was used to conduct the statistical analysis. Increased levels of galectin‐3, galectin‐3 binding protein in patients than the control group (p