ACE Research Journal of Microbiology and Biotechnology

  • ISSN Print: 2520-3975, ISSN Online:
  • Start Year: 2021
  • Volume: 3 (2023), Issue: 2

Evaluation of Serum TWEAK in Systemic Lupus Erythematosus (SLE) with and Without Clinically Evident Nephritis

Author: Tiba Mohammed Shakir, Raid Jassim Mohamed and Jalal Abed Altaai
Page: 56-62
Published online: 08 Nov 2023


Lupus nephritis (LN) is a form of glomerulonephritis that constitutes one of the most severe organ manifestations of the autoimmune disease systemic lupus erythematosus (SLE) Anders. LN was related to fibrosis in the kidney. As an important marker in the tumor necrosis factor (TNF) superfamily, TNF‐like weak inducer of apoptosis (TWEAK) has been given much attention concerning its role in regulating the pro‐inflammatory immune response, dysregulated expression of TWEAK, Fn14 has been reported in SLE, LN patients and in vivo, in vitro studies have discussed the significant role of TWEAK‐Fn14 axis in SLE. In this review, we will discuss the association of the TWEAKFn14 axis in lupus.