ACE Journal of Public Health and Community Medicine

  • ISSN Print: 2520-5633, ISSN Online:
  • Start Year: 2021
  • Volume: 4 (2024), Issue: 1

The Oxidative Stress Influence in Epigenetic Mechanisms and its Related with Diseases

Author: Shaimaa A. Al-Oubaidy
Page: 25-31
Published online: 05 Jun 2024


The present review was suggested to explain the effect of oxidative stress (OS) which promote by excessive generation of free radicals like reactive oxygen (ROS) or nitrogen species (RNS) from exo and endogenous factors in the cells in the epigenetic processing's included DNA methylation (DNAM), non‐coding RNA and histone modification, these mechanisms regulate gene expression that might be affected in wide range of diseases, oxidative stress impact in epigenetic in different levels included promote nucleotide modification, inhibition or eliminated specific enzymes activity, structural changes of proteins in these pathways, nevertheless, the essential free radicals function in cell processing, it implicated in up and/or down regulation of some gene expression via epigenetic alterations. significant contribution of OS in epigenetic changes via different mechanism, particularly in absence of antioxidant defense, that effect in cell components, changes in some physiological markers like hormones, enzymes, regulatory factors lead to tissues changes and organ dysfunction.