TY  - JOUR
T1  - Effect of Metformin Monotherapy Versus Omega 3 and Metformin Combination on Ovulatory Dysfunction and Hyperandrogenism State in Iraqi Women With PCOS
AU - Jalee Swadi, Asma
        AU - Ali Al?Burhan, Riyam Mmed
        
JO  - ACE Journal of Public Health and Community Medicine
VL  - 4
IS  - 1
SP  - 1
EP  - 7
PY  - 2024
DA  - 2001/08/19
SN  - 2520-5633
DO  - acejphcm.2024.1.7
UR  - https://theacepublications.com/article-detail.php?art=253-ACE-JPHCM
KW  - Ovarian function
KW  -Polycystic ovarian syndrome
KW  -Omega?3
AB  - Women with PCOS often have cycles that exceed 35 days in length may indicate
persistent an ovulation. Disruptions in ovulation can have detrimental
consequences such as infertility, endometrial hyperplasia and endometrial
tumor. In PCOS, clinical hyperandrogenism can be differentiated from
biochemical hyperandrogenism in females exhibiting symptoms such as acne,
alopecia, or hirsutism. To measure the influence of metformin and omega?3
management combination on ovulatory dysfunction and hyperandrogenism
state in women with PCOS. The existing interventional prospective training
comprised 90 sick with an age range of 18<40 years. Those patients were
identified with polycystic ovarian syndrome (PCOS) founded on Rotterdam
principles (Rotterdam, 2004) by 2 specialists in obstetrics and gynecology. The
patients were recruited from the Maternity and Pediatrics Teaching Hospital in
Adiwaniyah Province, Iraq. The training is dated posterior to September the 21st
2023 and extended to March 31st 2024.Following treatment, both
metformin+Omega3 and metformin alone were able to reduce mean
testosterone considerably (p<0.001 versus p<0.001, separately), however, the
amount of reduction caused by combination was more than that caused by
metformin alone significantly, 0.8 ng/dl versus 0.7 ng/dl, respectively (p<0.001).
Before treatment, there stayed no important variance in mean ovary size among
study grouping (p = 0.402), in addition both treatment approaches did not affect
mean ovary size significantly (p = 0.302). Both metformin+Omega3 and
metformin alone were able to reduce mean AFC significantly (p<0.001 versus
p<0.001, separately), however, the amounts of reduction in both grouping stood
comparable with no significant difference, 2.22 versus 2.66, respectively (p =
0.112). Both metformin+Omega3 and metformin alone were able to reduce
mean hirsutism score considerably (p<0.001 versus p<0.001, separately),
however, the amount of reduction caused by combination was > that caused by
metformin alone significantly, 1.82 versus 0.4, respectively (p<0.001) The use
of Omega3 has an efficient and safe synergistic effect when added to metformin
in improving ovarian function and androgen effect in PCOS.
ER  -