TY  - JOUR
T1  - Design, synthesizes and Insilco studyof 2-Mercaptobenzoxazole derivatives as progesterone antagonist
AU - Al-Tameemi, Sadeq
        AU - Hassooni, Hanan
        AU - Idrees, Buraq
        
JO  - ACE Journal of Public Health and Community Medicine
VL  - 3
IS  - 1
SP  - 1
EP  - 7
PY  - 2023
DA  - 2001/08/19
SN  - 2520-5633
DO  - acejphcm.2023.1.7
UR  - https://theacepublications.com/article-detail.php?art=201-ACE-JPHCM
KW  - Anticancer
KW  - Breast Cancer
KW  - Progesterone Antagonist
KW  - 2-Mercaptobenzoxazole
KW  - Alkylation.
AB  - Background:Cancer one of the most serious health problems today, and breast cancer most common cancer occur in woman’s use chemotherapy has disadvantage such as resistance and non-selectivity toward cancer cells,2-mercaptobenoxazole and its derivatives important heterocyclic compound in pharmaceutical chemistry as anticancer. The aim is synthesized various derivatives of 2-MBO and their structures confirmed through IR, 1H-NMR, 13C-NMR, DSC, and elemental analysis. The synthesized compounds were docking with progesterone receptors showing good binding energy affinity. All synthesized compounds were consistent with DSC, 1H-NMR, 13C-NMR, FT-IR, and elemental analysis, and docking against progesterone receptor. Our findings indicate the potency of ZS5as candidate for the development of anti-breast cancer.
ER  -