@article{ACEJPHCM202331201,
    title = {Design, synthesizes and Insilco studyof 2-Mercaptobenzoxazole derivatives as progesterone antagonist},
    journal = {ACE Journal of Public Health and Community Medicine},
    volume = {3},
    number = {1},
    pages = {1-7},
    year = {2023},
    issn = {2520-5633},
    doi = {acejphcm.2023.1.7},
    url = {https://theacepublications.com/article-detail.php?art=201-ACE-JPHCM},
    author = {Sadeq,Hanan and},
    keywords = {Anticancer, Breast Cancer, Progesterone Antagonist, 2-Mercaptobenzoxazole, Alkylation.},
    abstract = {Background:Cancer one of the most serious health problems today, and breast cancer most common cancer occur in woman’s use chemotherapy has disadvantage such as resistance and non-selectivity toward cancer cells,2-mercaptobenoxazole and its derivatives important heterocyclic compound in pharmaceutical chemistry as anticancer. The aim is synthesized various derivatives of 2-MBO and their structures confirmed through IR, 1H-NMR, 13C-NMR, DSC, and elemental analysis. The synthesized compounds were docking with progesterone receptors showing good binding energy affinity. All synthesized compounds were consistent with DSC, 1H-NMR, 13C-NMR, FT-IR, and elemental analysis, and docking against progesterone receptor. Our findings indicate the potency of ZS5as candidate for the development of anti-breast cancer.}
    }